The finance-dominated duchy has made hosting asteroid mining hopefuls a priority, announcing a €100 million (US$113 million) fund for space mineral explorers and a €200 million line of credit for companies to move their headquarters to the country last year.
Now, space veteran Russia wants to join in.
Reuters has quoted Russian deputy prime minister Tatyana Golikova on a trip to Luxembourg on the possibility of a tie-up.
"In January we offered Luxembourg a framework agreement on cooperation in the use of (mining) exploration in space," she said.
"We expect an answer from Luxembourg."
The private companies looking at asteroid mining have largely escaped the strict rules around investor promises their earth-bound contemporaries have to follow.
This has led to promises of probes this year and next from several companies.